- Transdermal permeation of diterpene forskolin, a natural compound isolated from roots of Coleus forskohlii (Briq.), was evaluated in Franz diffusion cell system utilizing skin graft
- The permeation of forskolin was enhanced when the concentration of Tetrahydropiperine was 5% of forskolin concentration
| Time (min) |
Forskolin Release Control (mg) |
Forskolin Release with THP (mg) |
Increase in release (% of forskolin) |
|---|---|---|---|
| 15 | 1.28 | 1.64 | 28.12 |
| 30 | 4.05 | 5.64 | 39.25 |
| 60 | 8.45 | 8.88 | 5.09 |
Transdermal permeation of diterpene forskolin in the presence of THP
Effect of THP on the dermal penetration of forskolin