Transdermal permeation of diterpene forskolin, a natural compound isolated from roots of Coleus forskohlii (Briq.), was evaluated in Franz diffusion cell system utilizing skin graft
The permeation of forskolin was enhanced when the concentration of Tetrahydropiperine was 5% of forskolin concentration
Time (min)
Forskolin Release Control (mg)
Forskolin Release with THP (mg)
Increase in release (% of forskolin)
15
1.28
164
28.12
30
4.05
5.64
39.25
60
8.45
8.88
5.09
Transdermal permeation of diterpene forskolin in the presence of THP
Effect of THP on the dermal penetration of forskolin
