Efficacy study with forskolin

  • Transdermal permeation of diterpene forskolin, a natural compound isolated from roots of Coleus forskohlii (Briq.), was evaluated in Franz diffusion cell system utilizing skin graft
  • The permeation of forskolin was enhanced when the concentration of Tetrahydropiperine was 5% of forskolin concentration
Time
(min)
Forskolin Release Control
(mg)
Forskolin Release with THP
(mg)
Increase in release
(% of forskolin)
151.2816428.12
304.055.6439.25
608.458.885.09
Transdermal permeation of diterpene forskolin in the presence of THP
cosmoperine
Effect of THP on the dermal penetration of forskolin