Cosmoperine® is Tetrahydropiperine obtained from black pepper using a proprietary process. When included in formulations with other biological actives, it enhances their bioavailability and utilization. Our studies with various products like Green tea, Coleus forskohlii extract and Tetrahydrocurcuminoids showed increased topical permeation. Clinically evaluated at levels of 0.01% and 0.1% Cosmoperine® showed no signs of dermal or ocular irritation.
The active sample resulted in 100 % diffusion of the BMDP within the first 10 minutes
The permeation of forskolin was enhanced when the concentration of Tetrahydropiperine was 5% of forskolin concentration
Green tea polyphenols
The solution containing 1% THP and 3 mg/ml of green tea polyphenols resulted in significant increase of the polyphenol permeation as compared to control without the THP Green tea polyphenols